Miyasaka, Yuhei and Komatsu, Shuichiro and Abe, Takanori and Kubo, Nobuteru and Okano, Naoko and Shibuya, Kei and Shirai, Katsuyuki and Kawamura, Hidemasa and Saitoh, Jun-ichi and Ebara, Takeshi and Ohno, Tatsuya (2021) Comparison of Oncologic Outcomes between Carbon Ion Radiotherapy and Stereotactic Body Radiotherapy for Early-Stage Non-Small Cell Lung Cancer. Cancers, 13 (2). p. 176. ISSN 2072-6694
cancers-13-00176-v2.pdf - Published Version
Download (1MB)
Abstract
Lung cancer is a leading cause of cancer-related deaths worldwide. Radiotherapy is an essential treatment modality for inoperable non-small cell lung cancer (NSCLC). Stereotactic body radiotherapy (SBRT) is the standard treatment for early-stage NSCLC because of its favorable local control (LC) compared to conventional radiotherapy. Carbon ion radiotherapy (CIRT) is a kind of external beam radiotherapy characterized by a steeper dose distribution and higher biological effectiveness. Several prospective studies have shown favorable outcomes. However, there is no direct comparison study between CIRT and SBRT to determine their benefits in the management of early-stage NSCLC. Thus, we conducted a retrospective, single-institutional, and contemporaneous comparison study, including propensity score-adjusted analyses, to clarify the differences in oncologic outcomes. The 3-year overall survival (OS) was 80.1% in CIRT and 71.6% in SBRT (p = 0.0077). The 3-year LC was 87.7% in the CIRT group and 79.1% in the SBRT group (p = 0.037). Multivariable analyses showed favorable OS and LC in the CIRT group (hazard risk [HR] = 0.41, p = 0.047; HR = 0.30, p = 0.040, respectively). Log-rank tests after propensity score matching and Cox regression analyses using propensity score confirmed these results. These data provided a positive efficacy profile of CIRT for early-stage NSCLC.
Item Type: | Article |
---|---|
Subjects: | Open Asian Library > Medical Science |
Depositing User: | Unnamed user with email support@openasianlibrary.com |
Date Deposited: | 11 Jan 2023 12:50 |
Last Modified: | 24 Oct 2024 04:05 |
URI: | http://publications.eprintglobalarchived.com/id/eprint/27 |